Though there is no connection with 1st Rank Raju, here also Raju is a young student who becomes a software engineer. Raju Kannada Medium is about his life in a small village where he first falls in love and loses his father. These teach him some lessons about life and love. Every time he learns a new lesson he writes it down in a special book his father had given him when he was a small boy.
When Raju’s friends in the village become busy with their family life and jobs, he decides to go to Bengaluru looking for a good job. He has language problems because his English is not good but he always loves the language of Kannada and becomes known for it.
In Bengaluru he meets Avantika Shetty who is working in the same company. First Raju feels she is above his ‘level’ but then he falls in love with her. There are complications and when Raju becomes really desperate he meets Sudeep who is the richest businessman in India. Sudeep gives him important advice about life and Raju continues his journey learning new lessons, having new experiences and meeting new people.